There have been a total of three cases of monkeypox reported in the United States since 200 The first reported case was in 2003 in a pet prairie dog that had been imported from Ghana. A 2003 study by the U.
S. Centers for Disease Control and Prevention (CDC) found two additional cases of monkeypox in humans in the United States, both of which were linked to direct contact with infected rodents from Africa.
Overall, the number of reported cases of monkeypox in the United States is quite small.