Monkeypox usually takes from 7-14 days from first exposure for any symptoms of the virus to appear. The average incubation period of the virus is 10–14 days. Milder cases may take up to 21 days for signs and symptoms to appear.
Monkeypox generally follows the pattern of an initial fever, headache, fatigue, and a rash-like cough. The rash spreads slowly from the face and then to other parts of the body.
The rash evolves and forms small vesicles or tiny fluid-filled blisters that come together into plaque-like layers on the skin. The rash scabs and falls off after about 2–4 weeks.